MAINTENANCE LENALIDOMIDE IN NEWLY DIAGNOSED TRANSPLANT ELIGIBLE AND NON-ELIGIBLE MYELOMA PATIENTS; PROFILING SECOND PRIMARY MALIGNANCIES IN 4358 PATIENTS TREATED IN THE MYELOMA XI TRIALRESEARCH IN CONTEXT

Summary: Background: Early trials of long-term lenalidomide use reported an increased incidence of second primary malignancy (SPM), including acute myeloid leukaemia and myelodysplastic syndrome.Later, meta-analysis suggested the link to be secondary to lenalidomide in combination with melphalan.Methods: Myeloma XI is a large, phase III randomised

This article analyses the international sanctions imposed on Russia by the EU as a result of the annexation of Crimea and the conflict in Donbass, and their impact in political and economic terms on member states, crimson tint dunks on certain economic sectors and on Russia.It also addresses how the diversity of positions within the European Counci

Context: Three-dimensional seal of the root canal space has always been challenging.The incorporation of gutta-percha and sealer prevents microleakage by bacteria, ensuring a shielded root canal space.However, the penetration of sealer to various depths within the root canal has always been looked with curiosity.Aims: Thus, the present in vitro stu